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Ischemia is defined as a decrease in cerebral circulation due to blockage of a cerebral artery and almost more than 80% of all strokes considered being the ischemic stroke

Ischemia is defined as a decrease in cerebral circulation due to blockage of a cerebral artery and almost more than 80% of all strokes considered being the ischemic stroke (Kunz et al., 2010). Acute ischemic stroke commonly occurs due to embolic stroke, thrombotic stroke, systemic hypoperfusion, or venous thrombosis (Deb et al., 2010). Necrotic regions in the center and surrounding apoptotic penumbral zone are the main histopathological findings in brain tissue following ischemic stroke (Mattson et al., 2001). Necrotic cell death occurs in a few minutes after injury and permanently results in the loss of tissues (Yuan et al., 2009). In the penumbra region, which can survive for a certain period, circulation of the tissue and viability of cells are provided by remaining cerebral blood flow and the period of flow reduction (Kunz et al., 2010). The penumbra of focal ischemia has a considerable clinical impact since this region remains viable and can be reactivated by increasing the blood flow (Hossmann, 1994). Penumbra of MCA model of stroke is similar to the one produced in the human stroke. In the photothrombosis model produced by Rose Bengal, the lesions lack penumbra because the vasogenic edema and breakdown of the blood-brain barrier (BBB) take place within a few minutes (Kumar and Gupta, 2016).